The “Chimeric Antigen Receptor T-Cell Therapy Pipeline Insight, 2023,” report provides comprehensive insights about 300+ companies and 300+ pipeline drugs in Chimeric Antigen Receptor T-Cell Therapy pipeline landscape. It covers the Chimeric Antigen Receptor T-Cell Therapy pipeline drug profiles, including Chimeric Antigen Receptor T-Cell Therapy clinical trials and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
In the Chimeric Antigen Receptor T-Cell Therapy Pipeline Report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, Chimeric Antigen Receptor T-Cell Therapy NDA approvals (if any), and product development activities comprising the technology, Chimeric Antigen Receptor T-Cell Therapy collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Key takeaways from the Chimeric Antigen Receptor T-Cell Therapy Pipeline Report
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Chimeric Antigen Receptor T-Cell Therapy Overview
Chimeric antigen receptor (CAR) T-cell therapy is a kind of cancer treatment that uses specially aletered T-cells- a part of the immune system. It seeks to sharpen and strengthen the immune system’s power to fight the cancer cells. the A sample of a patient’s T cells are collected from the blood, then modified to produce special structures called chimeric antigen receptors (CARs) on their surface. When these CAR T cells are reinfused into the patient, the new receptors enable them to latch onto a specific antigen on the patient’s tumor cells and kill them.
Recent Developments Activities in the Chimeric Antigen Receptor T-Cell Therapy Treatment Landscape
For further information, refer to the detailed Chimeric Antigen Receptor T-Cell Therapy Unmet Needs, Chimeric Antigen Receptor T-Cell Therapy Market Drivers, and Chimeric Antigen Receptor T-Cell Therapy Market Barriers, click here for @ Chimeric Antigen Receptor T-Cell Therapy Ongoing Clinical Trial Analysis
Chimeric Antigen Receptor T-Cell Therapy Emerging Drugs Profile
JWCAR029: JW Therapeutics
JWCAR029 is a Chimeric Antigen Receptor T-Cell Therapy cell product targeting CD19, which is intended to treat late-stage lymphoma and leukemia (Second-line therapy or greater). Initially, JWCAR029 is being studied for the treatment of B-cell malignancies focusing on relapsed and refractory DCBCL. In June 2020, the National Medical Products Administration (“NMPA”) accepted for review its NDA relating to relma-cel as a third-line treatment for DLBCL. The drug is in preregistration phase for the treatment of diffuse large B-cell lymphoma.
CEA CAR T: Sorrento Therapeutics
Sorrento Therapeutics through its wholly-owned subsidiary TNK Therapeutics is developing CEA CAR T. It is a CAR T-cells targeting carcinoembryonic antigen (CEA). The drug is being studied in phase II/III stage of development for the treatment of Malignant Tumor of Pancreas Metastatic to Liver.
Descartes-11: Cartesian Therapeutics
Descartes-011 are autologous CD8+ T-cells expressing an anti-BCMA chimeric antigen receptor. Descartes-11 is currently in phase II clinical trials to treat patients with multiple myeloma in an outpatient setting.
CNCT19: CASI Pharmaceuticals/Juventas Cell Therapy
CNCT19 is being developed by CASI Pharmaceuticals in collaboration with Juventas Cell Therapy. CNCT19 is currently in Phase II for Non-Hodgkin’s Lymphoma, Relapsed or Refractory Acute Lymphoblastic Leukemia and Phase I/II for Large B-cell Lymphoma and Phase I for Relapsed or Refractory Hematological Malignancies.
CTL119: Novartis
CTL119 (CD19 CAR) is a humanized CD19 CAR under development by Novartis in collaboration with the University of Pennsylvania and currently is in Phase II stage for the treatment of Acute Lymphoid Leukemia. CTL119 is produced with a patient’s T-cells, some of which are removed and then reprogrammed in Penn’s Clinical Cell and Vaccine Production Facility with a gene transfer technique designed to demonstrate the T cells to target and kill tumor cells. The engineered cells contain an antibody-like protein known as a CAR, which is designed to bind to CD19 protein on the surface of cancerous B cells. The modified “hunter” cells are then infused back into the patient’s body, where they multiply and are believed to attack the cancer cells.
KTE-X19: Gilead Sciences
KTE-X19 is an investigational, autologous, CD19 CAR T-cell therapy. The drug uses the XLP manufacturing process that includes T-cell selection and lymphocyte enrichment. KTE-X19 is currently in clinical evaluation for the treatment of Precursor B-cell lymphoblastic leukemia/lymphoma, Non-Hodgkin’s lymphoma, and chronic lymphocytic leukemia (CLL).
CART-19/22: Shanghai UniChimeric Antigen Receptor T-Cell Therapyherapy Bio-medicine Technology
Shanghai UniChimeric Antigen Receptor T-Cell Therapyherapy Bio-medicine Technology is developing CART-19/22 for the treatment of B-Cell Leukemia and currently, it is in Phase II clinical trial. The potential therapy is CD19/CD22 chimeric antigen receptor engineered T cell immunotherapy (CART).
Chimeric Antigen Receptor T-Cell Therapy Pipeline Therapeutics Assessment
There are approx. 300+ key companies which are developing the therapies for Chimeric Antigen Receptor T-Cell Therapy. The companies which have their Chimeric Antigen Receptor T-Cell Therapy drug candidates in the most advanced stage, i.e. pregistration include, JW therapeutics.
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Scope of the Chimeric Antigen Receptor T-Cell Therapy Pipeline Report
Dive deep into rich insights for drugs for Chimeric Antigen Receptor T-Cell Therapy Market Drivers and Chimeric Antigen Receptor T-Cell Therapy Market Barriers, click here @ Chimeric Antigen Receptor T-Cell Therapy Unmet Needs and Analyst Views
Table of Content
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